Chemical Structure : USP15 inhibitor Z86
CAS No.:
1448711-61-2
USP15 inhibitor Z86
Catalog No.: PC-27904Not For Human Use, Lab Use Only.
USP15 inhibitor Z86 is a small molecule USP15 inhibitor, promotes the ubiquitination and degradation of Smad2/3 and disrupts TGF-β/Smad2/3 signaling pathway, does not inhibit USP8 and USP4.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
USP15 inhibitor Z86 is a small molecule USP15 inhibitor, promotes the ubiquitination and degradation of Smad2/3 and disrupts TGF-β/Smad2/3 signaling pathway, does not inhibit USP8 and USP4.
Z86 also is a Wnt signaling inhibitor, selectively inhibits the growth of CRC cells with constitutive Wnt signaling and caused obvious G1-phase arrest of the cell cycle.
Z86 inhibits GSK3β (Ser9) phosphorylation, leading to its overactivation and promoting the phosphorylation and degradation of β-catenin.
Z86 is also a novel PI3Kα inhibitor with potent inhibitory efficiency on PI3K-mediated CRCs growth and migration.
Physicochemical Properties
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M.Wt
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408.50
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Formula
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C27H24N2O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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isopropyl 9-ethyl-1- (naphthalen-1-yl)-9H-pyrido[3,4-b]indole-3- carboxylate
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References
1. Li X, et al. Novel beta-carbolines against colorectal cancer cell growth via inhibition of Wnt/beta-catenin signaling. Cell Death Discov. 2015;1:15033.
2. Nie S, et al. beta-carboline derivative Z86 attenuates colorectal cancer cell proliferation and migration by directly targeting PI3K. Nat Prod Bioprospect. 2024;14(1):3.
3. Wang Y, et al. Nat Prod Bioprospect. 2026 Aug 28;16(1):84.
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