USP20 inhibitor C2

Chemical Structure : USP20 inhibitor C2

Catalog No.: PC-27899Not For Human Use, Lab Use Only.

USP20 inhibitor C2 is a small molecule Ubiquitin-Specific Protease 20 (USP20) inhibitor with IC50 of 13.55 uM (300 nM Ub-Rho110 as substrate), directly deubiquitinates and stabilizes fatty acid synthase (FASN), suppresses de novo lipogenesis (DNL) to alleviate MASLD.

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Biological Activity

USP20 inhibitor C2 is a small molecule Ubiquitin-Specific Protease 20 (USP20) inhibitor with IC50 of 13.55 uM (300 nM Ub-Rho110 as substrate), directly deubiquitinates and stabilizes fatty acid synthase (FASN), suppresses de novo lipogenesis (DNL) to alleviate MASLD.

Physicochemical Properties

M.Wt	400.43
Formula	C24H20N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[2-(4-ethoxyphenyl)-4-oxo-4H-chromen-6-yl]-1-phenylurea

References

1. Ma X, et al. Pharmacol Res. 2026 Aug 19;232:108406.

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