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USP25 and 28 inhibitor AZ2

Chemical Structure : USP25 and 28 inhibitor AZ2

CAS No.: 2165322-95-0

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USP25 and 28 inhibitor AZ2 (AZ2)

Catalog No.: PC-60026Not For Human Use, Lab Use Only.

USP25 and 28 inhibitor AZ2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    USP25 and 28 inhibitor AZ2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.
    USP25 and 28 inhibitor AZ2 shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.).
    USP25 and 28 inhibitor AZ2 demonstrates target engagement against both USP25 and USP28 in cells, elicits modulation of both the total levels and the half-life of the c-Myc oncoprotein in cells, and also induces apoptosis and inhibits cell viability in a range of cancer cell lines.

    Physicochemical Properties

    M.Wt 420.226
    Formula C17H17BrF3NO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((5-bromo-2-((3-(trifluoromethoxy)benzyl)oxy)benzyl)amino)ethan-1-ol

    References

    1. Wrigley JD, et al. ACS Chem Biol. 2017 Nov 28. doi: 10.1021/acschembio.7b00334.

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