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Chemical Structure : USP25 and 28 inhibitor AZ2
Catalog No.: PC-60026Not For Human Use, Lab Use Only.
USP25 and 28 inhibitor AZ2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.
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USP25 and 28 inhibitor AZ2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.
USP25 and 28 inhibitor AZ2 shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.).
USP25 and 28 inhibitor AZ2 demonstrates target engagement against both USP25 and USP28 in cells, elicits modulation of both the total levels and the half-life of the c-Myc oncoprotein in cells, and also induces apoptosis and inhibits cell viability in a range of cancer cell lines.
| M.Wt | 420.226 | |
| Formula | C17H17BrF3NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wrigley JD, et al. ACS Chem Biol. 2017 Nov 28. doi: 10.1021/acschembio.7b00334.
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