Chemical Structure : USP28 inhibitor 19
CAS No.:
2592454-13-0
USP28 inhibitor 19
Catalog No.: PC-20592Not For Human Use, Lab Use Only.
USP28 inhibitor 19 is a potent, selective USP28 inhibitor with IC50 of 1.1 uM, does not inhibit USP7 and LSD1 (IC50>100 uM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
USP28 inhibitor 19 is a potent, selective USP28 inhibitor with IC50 of 1.1 uM, does not inhibit USP7 and LSD1 (IC50>100 uM).
USP28 inhibitor 19 exerted good cell inhibitory activities against HGC-27 and MKN45 cells (IC50=0.61 and 1.49 μmol/L, respectively).
USP28 inhibitor 19 (20 uM) decreased expression of USP28 in HGC-27 cells, thus leading to decreased expression of its substrates LSD1 and total c-Myc.
USP28 inhibitor 19 induced cellular degradation of USP28, LSD1 and total c-Myc in HGC-27 cells.
USP28 inhibitor 19 inhibited colony formation and proliferation of gastric cancer cells, induced cell apoptosis and cell cycle arrest in HGC-27 cells.
Physicochemical Properties
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M.Wt
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377.90
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Formula
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C16H20ClN7S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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NCCNC1=C(N=NN2CC3=CC=C(Cl)C=C3)C2=NC(SCCC)=N1
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References
1. Zhenzhen Liu, et al. Acta Pharm Sin B. 2020 Aug;10(8):1476-1491.
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