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USP30Inh-1

Chemical Structure : USP30Inh-1

CAS No.: 2018353-40-5

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USP30Inh-1 (USP30 inhibitor 1)

Catalog No.: PC-72254Not For Human Use, Lab Use Only.

USP30Inh-1 is a potent, selective small molecule USP30 inhibitor with IC50 of 15-30 nM (inhibition of USP30-mediated cleavage of Ub-Rho110).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    USP30Inh-1 is a potent, selective small molecule USP30 inhibitor with IC50 of 15-30 nM (inhibition of USP30-mediated cleavage of Ub-Rho110).
    USP30Inh-1 is anticipated to form a covalent linkage with the catalytic cysteine within the USP30 active site.
    USP30Inh-1 demonstrated good selectivity against >40 known DUB enzymes at 1 uM.
    USP30Inh-1 (1-10 uM) enhances mitoKeima signal in SHSY5Y cell, increases p-Ser65-Ub in dopaminergic neurones and astrocytes, as well as in Parkin heterozygote fibroblasts.

    Physicochemical Properties

    M.Wt 325.372
    Formula C17H19N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-N-(1-cyanopyrrolidin-3-yl)-3-methoxy-4-(1-methyl-1H-pyrazol-4-yl)benzamide

    References

    1. Tsefou E, et al. Biochem J. 2021 Dec 10;478(23):4099-4118.

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