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Chemical Structure : USP30Inh-1
Catalog No.: PC-72254Not For Human Use, Lab Use Only.
USP30Inh-1 is a potent, selective small molecule USP30 inhibitor with IC50 of 15-30 nM (inhibition of USP30-mediated cleavage of Ub-Rho110).
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USP30Inh-1 is a potent, selective small molecule USP30 inhibitor with IC50 of 15-30 nM (inhibition of USP30-mediated cleavage of Ub-Rho110).
USP30Inh-1 is anticipated to form a covalent linkage with the catalytic cysteine within the USP30 active site.
USP30Inh-1 demonstrated good selectivity against >40 known DUB enzymes at 1 uM.
USP30Inh-1 (1-10 uM) enhances mitoKeima signal in SHSY5Y cell, increases p-Ser65-Ub in dopaminergic neurones and astrocytes, as well as in Parkin heterozygote fibroblasts.
| M.Wt | 325.372 | |
| Formula | C17H19N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tsefou E, et al. Biochem J. 2021 Dec 10;478(23):4099-4118.
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