USP3 inhibitor 59

Chemical Structure : USP3 inhibitor 59

Catalog No.: PC-21559Not For Human Use, Lab Use Only.

USP3 inhibitor 59 is a relatively specific small molecule chemical handle with SPR value of 14 uM, binds to zinc-finger ubiquitin binding domain (ZnF-UBD).

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Biological Activity

USP3 inhibitor 59 is a relatively specific small molecule chemical handle with SPR value of 14 uM, binds to zinc-finger ubiquitin binding domain (ZnF-UBD).
USP3 inhibitor 59 displays 5-times selective for USP3 over USP5, USP16, and HDAC6 ZnF-UBDs.
USP3 inhibitor 59 does not inhibit USP3 catalytic activity.
USP3 inhibitor 59 could be used to interrogate the function of the USP3 Znf-UBD and the consequences of recruiting USP3 to ubiquitylated proteins.

Physicochemical Properties

M.Wt	373.38
Formula	C17H15N3O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(1H-pyrrolo[2,3-b]pyridine-3-sulfonamido)phenyl)-4-oxobutanoic acid

References

1. Mandeep K. Mann, et al. ACS Omega 2023.

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