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USP5 inhibitor 64

Chemical Structure : USP5 inhibitor 64

CAS No.: 2851040-81-6

USP5 inhibitor 64 (USP5-IN-1)

Catalog No.: PC-72414Not For Human Use, Lab Use Only.

USP5 inhibitor 64 is a selective chemical probe (inhibitor) against USP5 deubiquitinase, binds to the USP5 ZnF-UBD (zinc-finger ubiquitin binding domain) with KD of 2.8 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

USP5 inhibitor 64 is a selective chemical probe (inhibitor) against USP5 deubiquitinase, binds to the USP5 ZnF-UBD (zinc-finger ubiquitin binding domain) with KD of 2.8 uM.
USP5 inhibitor 64 is selective over nine proteins containing structurally similar ZnF-UBD domains.
USP5 inhibitor 64 inhibits the USP5 catalytic cleavage of a di-ubiquitin substrate in an in vitro assay.

Physicochemical Properties

M.Wt 437.895
Formula C19H20ClN3O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

Chemical Name/SMILES

(5-((4-(4-chlorophenyl)piperidin-1-yl)sulfonyl)picolinoyl)glycine

References

1. Mandeep K Mann, et al. J Med Chem. 2021 Oct 28;64(20):15017-15036.

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