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USP7-797

Chemical Structure : USP7-797

CAS No.: 2413944-70-2

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USP7-797 (RAPT41)

Catalog No.: PC-38191Not For Human Use, Lab Use Only.

USP7-797 (RAPT41) is a novel potent selective inhibitor of USP7 with IC50 of 0.44 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    USP7-797 (RAPT41) is a novel potent selective inhibitor of USP7 with IC50 of 0.44 nM.
    USP7-797 (RAPT41) inhibits the growth of p53-mutant small cell lung cancer cell line H526 at a CC50 of 450 nM.
    USP7-797 (RAPT41) demonstrates tumor growth inhibition in both p53 wildtype and p53 mutant cancers.

    Physicochemical Properties

    M.Wt 510.049
    Formula C27H28ClN3O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-((7-(5-chloro-3-methyl-2-(((R)-morpholin-2-yl)methyl)phenyl)thieno[3,2-b]pyridin-2-yl)methyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione

    References

    1. Yamini M Ohol, et al. Mol Cancer Ther. 2020 Oct;19(10):1970-1980.

    2. Paul R Leger, et al. J Med Chem. 2020 May 28;63(10):5398-5420.

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