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USP7i-1

Chemical Structure : USP7i-1

CAS No.: 1381291-36-6

USP7i-1 (USP7 inhibitor 1, USP7-IN-1)

Catalog No.: PC-61935Not For Human Use, Lab Use Only.

USP7i-1 (USP7-IN-1) is a potent, selective USP7 inhibitor with IC50 of 77 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

USP7i-1 (USP7-IN-1) is a potent, selective USP7 inhibitor with IC50 of 77 uM.
USP7i-1 shows no inhibition of USP8, USP5, Uch-L1, Uch-L3 or caspase 3.
USP7i-1 inhibits the proliferation of HCT116 cells with GI50 of 67 uM.

Physicochemical Properties

M.Wt 425.913
Formula C23H24ClN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-chloro-3-((4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl)methyl)quinazolin-4(3H)-one

References

1. Weisberg EL, et al. Nat Chem Biol. 2017 Dec;13(12):1207-1215.

2. Kessler BM. Expert Opin Ther Pat. 2014 May;24(5):597-602.

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