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USP8 inhibitor RA-9

Chemical Structure : USP8 inhibitor RA-9

CAS No.: 919091-63-7

USP8 inhibitor RA-9 (RA-9)

Catalog No.: PC-72534Not For Human Use, Lab Use Only.

USP8 inhibitor RA-9 is a small molecule USP8 inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

USP8 inhibitor RA-9 is a small molecule USP8 inhibitor.
USP8 inhibitor RA-9 inhibits colony formation of breast, ovarian and cervical cancer cells with IC50 of <100 nM, completely abrogating colony formation at 0.3 uM.
USP8 inhibitor RA-9 inhibits deubiqutinating enzymes (DUB) and alters expression of DUB-regulated oncogenes and tumor suppressors.
USP8 inhibitor RA-9 directly suppress activities of major cellular DUB, such as UCH-L1, UCH-L3, USP2, USP5 and USP8, but do not inhibit Ataxin-3, A20CD, BAP1, Otubain 1, USP7/HAUSP or USP14.

Physicochemical Properties

M.Wt 365.34
Formula C19H15N3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3E,5E)-3,5-Bis(4-nitrobenzylidene)piperidin-4-one

References

1. Issaenko OA, et al. Cell Cycle. 2012 May 1;11(9):1804-17.

2. Treppiedi D, et al. Endocr Relat Cancer. 2021 Jun 28;28(8):573-582

3. Zhu Y, et al. Aging (Albany NY). 2021 Jun 3;13(11):14999-15012.

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