USP inhibitor 1 | USP33 inhibitor, USP4 inhibitor

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Chemical Structure : USP inhibitor 1

CAS No.: 2064106-47-2

USP inhibitor 1 (USP4 inhibitor)

Catalog No.: PC-73353Not For Human Use, Lab Use Only.

USP inhibitor 1 is an irreversible USP inhibitor with submicromolar IC50 of USP4 and its phylogenetic relative USP11, also functionally inhibits USP33, leading to CP110 instability and synergy with ATR inhibition.

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2 mg	$258	In stock
5 mg	$398	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

USP inhibitor 1 is an irreversible USP inhibitor with submicromolar IC50 of USP4 and its phylogenetic relative USP11, also functionally inhibits USP33, leading to CP110 instability and synergy with ATR inhibition in U2OS cells.

Physicochemical Properties

M.Wt	290.747
Formula	C15H15ClN2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-benzyl-4-(2-chloroacetyl)-1-methyl-1H-pyrrole-2-carboxamide

References

1. Ward JA, et al. ACS Chem Biol. 2016 Dec 16;11(12):3268-3272.

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USP inhibitor 1 (USP4 inhibitor)

Biological Activity

Physicochemical Properties

References

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