USP inhibitor 2 | USP4 inhibitor | Probechem Biochemicals

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Chemical Structure : USP inhibitor 2

USP inhibitor 2 (USP4 inhibitor)

Catalog No.: PC-73354Not For Human Use, Lab Use Only.

USP inhibitor 2 is a broad DUB inhibitor with IC50 of 0.04 and 0.21 uM for USP4 and USP11, also inhibits USP10/16/15/19 with submicromolar potency, forms a covalent adduct with USP11. USP inhibitor 2 does not inhibit USP5 (IC50>100 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

USP inhibitor 2 is a broad DUB inhibitor with IC50 of 0.04 and 0.21 uM for USP4 and USP11, also inhibits USP10/16/15/19 with submicromolar potency, forms a covalent adduct with USP11. USP inhibitor 2 does not inhibit USP5 (IC50>100 uM).

Physicochemical Properties

M.Wt	314.769
Formula	C17H15ClN2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-chloroacetyl)-N-(4-ethynylbenzyl)-1-methyl-1H-pyrrole-2-carboxamide

References

1. Ward JA, et al. ACS Chem Biol. 2016 Dec 16;11(12):3268-3272.

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