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USP inhibitor 2

Chemical Structure : USP inhibitor 2

CAS No.: 2064106-48-3

USP inhibitor 2

Catalog No.: PC-73354Not For Human Use, Lab Use Only.

USP inhibitor 2 is a broad DUB inhibitor with IC50 of 0.04 and 0.21 uM for USP4 and USP11, also inhibits USP10/16/15/19 with submicromolar potency, forms a covalent adduct with USP11. USP inhibitor 2 does not inhibit USP5 (IC50>100 uM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

USP inhibitor 2 is a broad DUB inhibitor with IC50 of 0.04 and 0.21 uM for USP4 and USP11, also inhibits USP10/16/15/19 with submicromolar potency, forms a covalent adduct with USP11. USP inhibitor 2 does not inhibit USP5 (IC50>100 uM).

Physicochemical Properties

M.Wt 314.769
Formula C17H15ClN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

1. Ward JA, et al. ACS Chem Biol. 2016 Dec 16;11(12):3268-3272.

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