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UVI 2008

Chemical Structure : UVI 2008

CAS No.: 1504556-86-8

UVI 2008 (UVI2008)

Catalog No.: PC-70296Not For Human Use, Lab Use Only.

UVI 2008 is a RARβ/γ agonist originated from TTNPB, is also a selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10) with IC50 of 6.1 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UVI 2008 is a RARβ/γ agonist originated from TTNPB, is also a selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10) with IC50 of 6.1 uM.
    UVI 2008 shows >10-fold selectivity over the closely related aldose reductase (AR, IC50=70 uM).

    Physicochemical Properties

    M.Wt 427.382
    Formula C24H27BrO2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (E)-3-bromo-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl)benzoic acid

    References

    1. Ruiz FX, et al. Chem Biol Interact. 2017 Feb 1. pii: S0009-2797(17)30109-6.

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