UVI 2008 | RARβ/γ agonist | Probechem Biochemicals

Chemical Structure : UVI 2008

UVI 2008 (UVI2008)

Catalog No.: PC-70296Not For Human Use, Lab Use Only.

UVI 2008 is a RARβ/γ agonist originated from TTNPB, is also a selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10) with IC50 of 6.1 uM.

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Biological Activity

UVI 2008 is a RARβ/γ agonist originated from TTNPB, is also a selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10) with IC50 of 6.1 uM.
UVI 2008 shows >10-fold selectivity over the closely related aldose reductase (AR, IC50=70 uM).

Physicochemical Properties

M.Wt	427.382
Formula	C24H27BrO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-bromo-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl)benzoic acid

References

1. Ruiz FX, et al. Chem Biol Interact. 2017 Feb 1. pii: S0009-2797(17)30109-6.

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UVI 2008 (UVI2008)

Biological Activity

Physicochemical Properties

References

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