UbV SP.1 | STAMBP inhibitor | Probechem Biochemicals

Chemical Structure : UbV SP.1

UbV SP.1 (SFSLT GKGTG IARKQ QQGTY VLRHR HSAS)

Catalog No.: PC-72760Not For Human Use, Lab Use Only.

UbV SP.1 is potent, selective inhibitor of STAMBP isopeptidase activity with KD of 0.05/0.18 uM for STAMBP/STAMBPL1, respectively.

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Biological Activity

UbV SP.1 is potent, selective inhibitor of STAMBP isopeptidase activity with KD of 0.05/0.18 uM for STAMBP/STAMBPL1, respectively.
UbV SP.1 showed no binding to two USP-family DUBs (USP7 and USP14), a JAMM-family DUB complex BRISC, or an OTU-family DUB OTUD1.
STAMBP is a member of the JAB1/MPN/MOV34 (JAMM) metalloprotease family of DUB enzymes.
UbV SP.1 binds both the full-length and the JAMM domain of STAMBP (STAMBPJAMM), far exceeding the reported small-molecule inhibitor BC-1471.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
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Solubility
Chemical Name/SMILES

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UbV SP.1 (SFSLT GKGTG IARKQ QQGTY VLRHR HSAS)

Biological Activity

Physicochemical Properties

References

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