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UbcH5c-IN-6d

Chemical Structure : UbcH5c-IN-6d

CAS No.: 2123480-72-6

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UbcH5c-IN-6d (UbcH5c inhibitor 6d)

Catalog No.: PC-60354Not For Human Use, Lab Use Only.

UbcH5c-IN-6d is a potent, specific, orally bioactive small-molecule inhibitor of ubiquitin-conjugating enzyme UbcH5c with Kd of 283 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

UbcH5c-IN-6d is a potent, specific, orally bioactive small-molecule inhibitor of ubiquitin-conjugating enzyme UbcH5c with Kd of 283 nM.
UbcH5c-IN-6d suppresses the activation of the NF-κB signaling pathway by selectively covalently binding to the Cys85 residue of UbcH5c.
UbcH5c-IN-6d exhibits potent anti-inflammatory activity against complete Freund’s adjuvant-induced adjuvant arthritis in vivo.

Physicochemical Properties

M.Wt 413.31
Formula C22H21BrO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3aS,9bR)-8-((2-Bromobenzyl)oxy)-6,9-dimethyl-3-methylene-3a,4,5,9b-tetrahydronaphtho[1,2-b]furan-2(3H)-one

References

1. Chen H, et al. J Med Chem. 2017 Aug 24;60(16):6828-6852.

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