Ubiquitin isopeptidase inhibitor I
(G5, NSC 144303, NSC144303)
Catalog No.: PC-42241Not For Human Use, Lab Use Only.
Ubiquitin isopeptidase inhibitor I (G5, NSC 144303) is a small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases, inhibits deubiquitinase YOD1.
Ubiquitin isopeptidase inhibitor I (G5, NSC 144303) is a small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases, inhibitsdeubiquitinase YOD1.
Ubiquitin isopeptidase inhibitor I (G5, NSC 144303) notably degraded PML/RARα protein and eradicated APL, particularly drug-resistant APL cells.
Ubiquitin isopeptidase inhibitor I (G5, NSC 144303) induce a unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with up-regu.lation of the BH3-only protein Noxa, stabilization of the IAP antagonist Smac, but also the involvement of the death receptor pathway.
