UniPR1331 |CAS:1809170-59-9 Probechem Biochemicals

Chemical Structure : UniPR1331

UniPR1331 (UniPR-1331)

Catalog No.: PC-35435Not For Human Use, Lab Use Only.

UniPR1331 (UniPR-1331) is a selective, orally available antagonist of Eph/ephrin interaction with pIC50 of 5.45, IC50 of 2.9 uM.

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Biological Activity

UniPR1331 (UniPR-1331) is a selective, orally available antagonist of Eph/ephrin interaction with pIC50 of 5.45, IC50 of 2.9 uM.
UniPR1331 demonstrates anti-angiogenic agent in endothelial cells, bioavailable in mice by the oral route and devoid of biological activity on G protein-coupled and nuclear receptors targeted by bile acid derivatives.
UniPR1331 blocks the tube formation of HBMVEC in a concentration-dependent manner with IC50 of 3.9 uM, dramatically inhibits vessel formation induced by VEGF165 in in vivo in the CAM assay, does not interfere with the kinase activity of VEGFR2.
UniPR1331 inhibits ephrin-A1 induced EphA2 phosphorylation decreasing EphA2 expression on U87MG cells, without interfering with the enzymatic activity of EphA2.
UniPR1331 prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice.

Physicochemical Properties

M.Wt	560.779
Formula	C35H48N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((R)-4-((3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoyl)-L-tryptophan

References

1. Festuccia C, et al. Oncotarget. 2018 May 11;9(36):24347-24363.

2. Castelli R, et al. Eur J Med Chem. 2015 Oct 20;103:312-24.

3. Vivo V, et al. Shock. 2017 Dec;48(6):681-689.

UniPR1331 (UniPR-1331)

Biological Activity

Physicochemical Properties

References

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