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Chemical Structure : Upadacitinib
CAS No.: 1310726-60-3
Catalog No.: PC-45653Not For Human Use, Lab Use Only.
Upadacitinib (ABT-494) is a potent and selective JAK1 inhibitor with celluar IC50 of 8 nM, biochemical IC50 of 40 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | $378 | In stock | |
| 250 mg | Get quote | ||
| 250 mg | Get quote |
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Upadacitinib (ABT-494) is a potent and selective JAK1 inhibitor with celluar IC50 of 8 nM, biochemical IC50 of 40 nM.
Upadacitinib (ABT-494) displays 74-fold and 50-fold selectivity over JAK2 and JAK3, respectively.
Upadacitinib (ABT-494) is a second-generation JAK inhibitor in development for rheumatoid arthritis.
| M.Wt | 380.3676 | |
| Formula | C17H19F3N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 22 mg/mL |
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| Chemical Name/SMILES |
1-Pyrrolidinecarboxamide, 3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-, (3S,4R)- |
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1. Genovese MC, et al. Arthritis Rheumatol. 2016 Dec;68(12):2857-2866.
2. Kremer JM, et al. Arthritis Rheumatol. 2016 Dec;68(12):2867-2877.
3. Mohamed MF, et al. Clin Pharmacokinet. 2016 Dec;55(12):1547-1558.
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