Chemical Structure : Upadacitinib
CAS No.:
1310726-60-3
Upadacitinib
(ABT-494, ABT494)
Catalog No. : PC-45653Not For Human Use, Lab Use Only.
Upadacitinib (ABT-494) is a potent and selective JAK1 inhibitor with celluar IC50 of 8 nM, biochemical IC50 of 40 nM.
Packing Price Stock Quantity 10 mg $98 In stock 0 1 2 3 4 5 25 mg $148 In stock 0 1 2 3 4 5 50 mg $238 In stock 0 1 2 3 4 5 100 mg $378 In stock 0 1 2 3 4 5 250 mg Get quote 0 1 2 3 4 5 250 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4565301
Biological Activity
Upadacitinib (ABT-494) is a potent and selective JAK1 inhibitor with celluar IC50 of 8 nM, biochemical IC50 of 40 nM.
Physicochemical Properties
M.Wt
380.3676
Formula
C17H19F3N6O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 22 mg/mL
Chemical Name/SMILES
1-Pyrrolidinecarboxamide, 3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-, (3S,4R)-
References
1. Genovese MC, et al. Arthritis Rheumatol.
2. Kremer JM, et al. Arthritis Rheumatol.
3. Mohamed MF, et al. Clin Pharmacokinet.
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