Catalog No.: PC-60863Not For Human Use, Lab Use Only.
V-11-0711 (V-11 0711) is a novel potent and selective choline kinase alpha (ChoKα) inhibitor with IC50 of 20 nM, with 11 fold less activity against ChoKβ.
V-11-0711 (V-11 0711) is a novel potent and selective choline kinase alpha (ChoKα) inhibitor with IC50 of 20 nM, with 11 fold less activity against ChoKβ.
V-11-0711 exhibits excellent selectivity against a panel of 50 kinases.
V-11-0711 impedes the catalytic activity and causes a reversible growth arrest, reduces phosphocholine (Pcho) in Hela cells with IC50 of <1 uM.
V-11-0711 also shows synergetic cytotoxic effects combined with chemotherapeutic temozolomide in some cancer cell lines.
