VCC234718

Chemical Structure : VCC234718

Catalog No.: PC-23461Not For Human Use, Lab Use Only.

Packing	Price	Stock	Quantity
25 mg		Get quote
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100 mg		Get quote

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Biological Activity

VCC234718 isa potent, specific small molecule inhibitor of Mtb inosine-5′-monophosphate dehydrogenase (IMPDH) GuaB2 with Ki of 100 nM, shows growth inhibitory activity against Mycobacterium tuberculosis (Mtb H37Rv, MIC90=2 uM).
VCC234718 has a 90% minimum inhibitory concentration (MIC90) of 5 μM against replicating H37Rv.
VCC234718 displays >30 fold selectivity for the Mtb GuaB2 enzyme over human IMPDH.

Physicochemical Properties

M.Wt	387.50
Formula	C20H25N3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclohexyl[4-(5-isoquinolinylsulfonyl)-1-piperazinyl]methanone

References

1. Singh V, et al. ACS Infect Dis. 2017 Jan 13;3(1):5-17.

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VCC234718

Biological Activity

Physicochemical Properties

References

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