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Chemical Structure : VCC234718
Catalog No.: PC-23461Not For Human Use, Lab Use Only.
VCC234718 isa potent, specific small molecule inhibitor of Mtb inosine-5′-monophosphate dehydrogenase (IMPDH) GuaB2 with Ki of 100 nM, shows growth inhibitory activity against Mycobacterium tuberculosis (Mtb H37Rv, MIC90=2 uM).
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VCC234718 isa potent, specific small molecule inhibitor of Mtb inosine-5′-monophosphate dehydrogenase (IMPDH) GuaB2 with Ki of 100 nM, shows growth inhibitory activity against Mycobacterium tuberculosis (Mtb H37Rv, MIC90=2 uM).
VCC234718 has a 90% minimum inhibitory concentration (MIC90) of 5 μM against replicating H37Rv.
VCC234718 displays >30 fold selectivity for the Mtb GuaB2 enzyme over human IMPDH.
| M.Wt | 387.50 | |
| Formula | C20H25N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Singh V, et al. ACS Infect Dis. 2017 Jan 13;3(1):5-17.
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