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VCC234718

Chemical Structure : VCC234718

CAS No.: 1278553-16-4

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VCC234718 (VCC-234718)

Catalog No.: PC-23461Not For Human Use, Lab Use Only.

VCC234718 isa potent, specific small molecule inhibitor of Mtb inosine-5′-monophosphate dehydrogenase (IMPDH) GuaB2 with Ki of 100 nM, shows growth inhibitory activity against Mycobacterium tuberculosis (Mtb H37Rv, MIC90=2 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    VCC234718 isa potent, specific small molecule inhibitor of Mtb inosine-5′-monophosphate dehydrogenase (IMPDH) GuaB2 with Ki of 100 nM, shows growth inhibitory activity against Mycobacterium tuberculosis (Mtb H37Rv, MIC90=2 uM).
    VCC234718 has a 90% minimum inhibitory concentration (MIC90) of 5 μM against replicating H37Rv.
    VCC234718 displays >30 fold selectivity for the Mtb GuaB2 enzyme over human IMPDH.

    Physicochemical Properties

    M.Wt 387.50
    Formula C20H25N3O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Cyclohexyl[4-(5-isoquinolinylsulfonyl)-1-piperazinyl]methanone

    References

    1. Singh V, et al. ACS Infect Dis. 2017 Jan 13;3(1):5-17.

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