VER-155008 | Hsp70 inhibitor | Probechem Biochemicals

Chemical Structure : VER-155008

CAS No.: 1134156-31-2

VER-155008 (VER155008)

Catalog No.: PC-42747Not For Human Use, Lab Use Only.

VER-155008 is a potent Hsp70 family (Hsc70/Hsp7/Grp78) inhibitor with Kd of 80 nM for Grp78.

Packing	Price	Stock
10 mg	$88	In stock
25 mg	$138	In stock
50 mg	$218	In stock
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

VER-155008 is a potent Hsp70 family (Hsc70/Hsp7/Grp78) inhibitor with Kd of 80 nM for Grp78.
VER-155008 shows cellular activity in HCT116 cells (GI50= 5uM), has similar potencies in both Grp78 and Hsp70.
VER-155008 inhibits the proliferation of human breast and colon cancer cell lines with GI50s of 5.3-14.4 uM, and induces Hsp90 client protein degradation in both HCT116 and BT474 cells.
VER-155008 induced caspase-3/7 dependent apoptosis in BT474 cells.

Physicochemical Properties

M.Wt	556.4006
Formula	C25H23Cl2N7O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 37 mg/mL
Chemical Name/SMILES	Adenosine, 5'-O-[(4-cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-

References

1. Macias AT, et al. J Med Chem. 2011 Jun 23;54(12):4034-41.

2. Massey AJ, et al. Cancer Chemother Pharmacol. 2010 Aug;66(3):535-45.

3. Kim SH, et al. Biochem Biophys Res Commun. 2014 Nov 7;454(1):36-41.

VER-155008 (VER155008)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.