Chemical Structure : VER-49009
CAS No.: 558640-51-0
Catalog No.: PC-49669Not For Human Use, Lab Use Only.
VER-49009 (CCT0129397, VER49009) is a potent, selective small-molecule inhibitor of Hsp90 with IC50 of 25 nM and Kd value of 78 nM, inhibits ATPase activity of full length yeast Hsp90 protein with IC50 of 0.14 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
VER-49009 (CCT0129397, VER49009) is a potent, selective small-molecule inhibitor of Hsp90 with IC50 of 25 nM and Kd value of 78 nM, inhibits ATPase activity of full length yeast Hsp90 protein with IC50 of 0.14 uM.
VER-49009 caused significant reduction in cellular levels of Raf-1, and the client protein CDK4.
VER-49009 potently inhibits HCT116 cell proliferation with GI50 of 0.26 uM.
VER-49009 caused induction of HSP72 and HSP27 alongside depletion of client proteins, including C-RAF, B-RAF, and survivin, and the protein arginine methyltransferase PRMT5.
VER-49009 exhibited mean cellular antiproliferative GI(50) values of685 nM against a human cancer cell line panel, induced cell cycle arrest and apoptosis.
M.Wt | 387.82 | |
Formula | C19H18ClN3O4 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
5-(5-Chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide |
1. Dymock BW, et al. J Med Chem. 2005 Jun 30;48(13):4212-5.
2. Sharp SY, et al. Mol Cancer Ther. 2007 Apr;6(4):1198-211.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright