Catalog No.: PC-35007Not For Human Use, Lab Use Only.
VGTI-A3-03 is a potent, highly virus-specific inhibitor of DENV replication with greatest activity against DENV serotype 2 (IC50=25 nM), directly binds DENV capsid protein.
VGTI-A3-03 is a potent, highly virus-specific inhibitor of DENV replication with greatest activity against DENV serotype 2 (IC50=25 nM), directly binds DENV capsid protein.
VGTI-A3-03 also demonstrates some inhibitory activity against DENV1, DENV4, and WNV.
VGTI-A3-03 does not inhibit viral RNA replication or secretion of viral particles, significantly diminishe secreted particles in treated cells, the binding pocket in the capsid molecule is at the dimerization interface.
VGTI-A3-03 is incorporated into virus particles released from infected cells.
