Catalog No.: PC-73101Not For Human Use, Lab Use Only.
VIT-2763 (Vamifeport, VIT2763) is an oral small molecule inhibitor of ferroportin, inhibits hepcidin binding to ferroportin with IC50 of 9 nM, blocks iron efflux.
VIT-2763 (Vamifeport, VIT2763) is an oral small molecule inhibitor of ferroportin, inhibits hepcidin binding to ferroportin with IC50 of 9 nM, blocks iron efflux.
VIT-2763 triggers ubiquitination and subsequent internalization and degradation of ferroportin.
Orally dosed VIT-2763 (30 mg/kg) decreased decrease in serum iron induced by hepcidin in rodents.
VIT-2763 decreased serum iron and prevented liver iron loading in Hbbth3/+ mice.
VIT-2763 significantly corrected anemia and improved RBC parameters in Hbbth3/+ mice, improved the ineffective erythropoiesis in BM and spleen.
VIT-2763 reduced the formation of insoluble α-globin aggregates and improved the elimination of mitochondria in RBCs.
VIT-2763 decreased apoptosis and extended the life span, reduced hypoxia response of RBCs.
