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VK-1850

Chemical Structure : VK-1850

CAS No.:

VK-1850 (VK1850;VK 1850)

Catalog No.: PC-36125Not For Human Use, Lab Use Only.

VK-1850 (VK1850) is a small-molecule inhibitor of the DNA binding activity of EBNA1 (Epstein-Barr nuclear antigen1).

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Biological Activity

VK-1850 (VK1850) is a small-molecule inhibitor of the DNA binding activity of EBNA1 (Epstein-Barr nuclear antigen1).
VK-1850 selectively inhibits proliferation of EBV-positive cells (C666-1 CC50=7.6 uM) but not similarly growing EBV-negative cells.
VK-1850 potently inhibits EBNA1-dependent OriP DNA replicationm without effect on EBNA1 protein expression in EBV-positive NPC cell line, C666-1.
VK-1850 significantly blocks EBV-positive tumor growth in vivo (10 mg/kg, intraperitoneally, TGI=91.3%), block EBV gene transcription and alter the cellular TGF-β signaling pathway in NPC tumor xenografts.

Physicochemical Properties

M.Wt 499.581
Formula C29H25NO5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl 3-((4-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy)phenyl)ethynyl)-2-(1H-indol-6-yl)benzoate

References

1. Messick TE, et al. Sci Transl Med. 2019 Mar 6;11(482). pii: eaau5612. doi: 10.1126/scitranslmed.aau5612.

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