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Chemical Structure : VK4-116
Catalog No.: PC-35905Not For Human Use, Lab Use Only.
VK4-116 (VK04-116) is a novel potent, highly selective dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, displays >1,000-fold selectivity over D2R.
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VK4-116 (VK04-116) is a novel potent, highly selective dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, displays >1,000-fold selectivity over D2R.
VK4-116 inhibits oxycodone-induced hyperlocomotion in mice and reduces oxycodone-induced locomotor sensitization.
VK4-116 also dose-dependently inhibites the acquisition of oxycodone-induced conditioned place preference (CPP) in rats.
| M.Wt | 485.025 | |
| Formula | C26H33ClN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. You ZB, et al. Neuropsychopharmacology. 2018 Nov 27. doi: 10.1038/s41386-018-0284-5.
2. Kumar V, et al. J Med Chem. 2016 Aug 25;59(16):7634-50.
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