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VK4-116

Chemical Structure : VK4-116

CAS No.: 1982347-43-2

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VK4-116 (VK04-116)

Catalog No.: PC-35905Not For Human Use, Lab Use Only.

VK4-116 (VK04-116) is a novel potent, highly selective dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, displays >1,000-fold selectivity over D2R.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    VK4-116 (VK04-116) is a novel potent, highly selective dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, displays >1,000-fold selectivity over D2R.
    VK4-116 inhibits oxycodone-induced hyperlocomotion in mice and reduces oxycodone-induced locomotor sensitization.
    VK4-116 also dose-dependently inhibites the acquisition of oxycodone-induced conditioned place preference (CPP) in rats.

    Physicochemical Properties

    M.Wt 485.025
    Formula C26H33ClN4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-(4-(3-Chloro-5-ethyl-2-methoxyphenyl)piperazin-1-yl)-3-hydroxybutyl)-1Hindole-2-carboxamide

    References

    1. You ZB, et al. Neuropsychopharmacology. 2018 Nov 27. doi: 10.1038/s41386-018-0284-5.

    2. Kumar V, et al. J Med Chem. 2016 Aug 25;59(16):7634-50.

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