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Chemical Structure : VLX600
CAS No.: 327031-55-0
Catalog No.: PC-72445Not For Human Use, Lab Use Only.
VLX600 (VLX-600) is a small molecule iron chelator and mitochondrial oxidative phosphorylation (OXPHOS) inhibitor, targets quiescent tumor cells and to inhibit mitochondrial respiration.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | $358 | In stock | |
| 250 mg | Get quote |
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VLX600 (VLX-600) is a small molecule iron chelator and mitochondrial oxidative phosphorylation (OXPHOS) inhibitor, targets quiescent tumor cells and to inhibit mitochondrial respiration.
VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation, displays tumour growth inhibition in vivo. decrease mitochondrial energy production, an effect poorly tolerated by metabolically stressed tumor cells.
VLX600 inhibits a number of colon cancer cell lines with IC50 of 1 uM.
In KitV558del/+ mice, VLX600 alone did not induce tumor cell death, but had a profound antitumor effect when combined with imatinib.
| M.Wt | 317.356 | |
| Formula | C17H15N7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[1-(2-[6-Methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl]hydrazin-1-ylidene)ethyl]pyridine |
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1. Zhang X, et al. Nat Commun. 2014;5:3295.
2. Fryknäs M, et al. Sci Rep. 2016 Dec 7;6:38343.
3. Antonescu CR, et al. Clin Cancer Res. 2018 Feb 15;24(4):972-984.
4. Karlsson H, et al. Oncotarget. 2019 Sep 3;10(51):5372-5382.
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