VP 21-04 | HO-1 inhibitor | Probechem Biochemicals

Chemical Structure : VP 21-04

VP 21-04 (VP21-04)

Catalog No.: PC-23515Not For Human Use, Lab Use Only.

VP 21-04 is a potent, selective Heme oxygenase-1 (HO-1) inhibitor with IC50 of 0.9 uM, displays 42-fold selective over HO-2 (IC50=38 uM).

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Biological Activity

VP 21-04 is a potent, selective Heme oxygenase-1 (HO-1) inhibitor with IC50 of 0.9 uM, displays 42-fold selective over HO-2 (IC50=38 uM).
VP 21-04 showed strong cytotoxic activity against melanoma and breast cancer cell lines.
VP21-04 exhibited cytotoxic activity towards SK-MEL-5 and MDA-MB-468 cell lines both overexpressing HO-1.
VP21-04 has been encapsulated in NLC to enhance its water solubility, and ADMET profile.

Physicochemical Properties

M.Wt	475.33
Formula	C21H22IN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(1H-imidazol-1-yl)butoxy)-N-benzyl-5-iodobenzamide

References

1. Virzì NF, et al. Int J Pharm. 2024 Nov 23:124997.

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VP 21-04 (VP21-04)

Biological Activity

Physicochemical Properties

References

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