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Chemical Structure : VPAC2 antagonist 1
Catalog No.: PC-20663Not For Human Use, Lab Use Only.
VPAC2 antagonist 1 is a small molecule human vsoactive intestinal peptide receptor-2 (hVIPR2, hVPAC2 receptor) antagonist, inhibits VPAC2-mediated cAMP accumulation with IC50 of 3.8 uM and the ligand-activated beta-arrestin2 binding with IC50 of 2.3 uM.
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VPAC2 antagonist 1 is a small molecule human vsoactive intestinal peptide receptor-2 (hVIPR2, hVPAC2 receptor) antagonist, inhibits VPAC2-mediated cAMP accumulation with IC50 of 3.8 uM and the ligand-activated beta-arrestin2 binding with IC50 of 2.3 uM.
VPAC2 antagonist 1 is a specific VPAC2 antagonist with no detectable agonist or antagonist activities on VPAC(1) or PAC(1).
VPAC2 antagonist 1 is completely inactive on the closely related mouse VPAC2.
VPAC2 antagonist 1 is the first small molecular antagonist that is specific for VPAC(2), and the only VPAC(2) antagonist molecule known to date that allosterically interacts with the 7TM region.
| M.Wt | 539.60 | |
| Formula | C27H29N3O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Alan Chu, et al. Mol Pharmacol. 2010 Jan;77(1):95-101.
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