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VPC-18005

Chemical Structure : VPC-18005

CAS No.: 2242480-48-2

VPC-18005 (VPC18005)

Catalog No.: PC-61463Not For Human Use, Lab Use Only.

VPC-18005 (VPC18005) is a novel small molecule ERG (ETS-related gene) antagonist that inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, disrupts the ERG binding to DNA (Kd=250 uM).

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Biological Activity

VPC-18005 (VPC18005) is a novel small molecule ERG (ETS-related gene) antagonist that inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, disrupts the ERG binding to DNA (Kd=250 uM).
VPC-18005 markedly decreases SOX9 expression, inhibits migration and invasion of ERG-overexpressing prostate cancer cells in vitro, and reduces metastasis in a zebrafish xenograft model.

Physicochemical Properties

M.Wt 319.379
Formula C15H17N3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((R,E)-2-(((E)-4-isopropylbenzylidene)hydrazono)-4-oxothiazolidin-5-yl)acetic acid

References

1. Butler MS, et al. Oncotarget. 2017 Jun 27;8(26):42438-42454.

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