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VPC-70063

Chemical Structure : VPC-70063

CAS No.: 13571-44-3

VPC-70063 (VPC70063)

Catalog No.: PC-49220Not For Human Use, Lab Use Only.

VPC-70063 (VPC70063) is a small molecule Myc inhibitor that inhibits Myc-Max transcriptional activity with IC50 of 8.9 uM in c-Myc luciferase reporter assay in LNCaP cells, disrupts the interaction of Myc-Max with DNA.

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Biological Activity

VPC-70063 (VPC70063) is a small molecule Myc inhibitor that inhibits Myc-Max transcriptional activity with IC50 of 8.9 uM in c-Myc luciferase reporter assay in LNCaP cells, disrupts the interaction of Myc-Max with DNA.
VPC-70063 inhibits Myc-driven cell proliferation of LNCaP cell with IC50 of 2.5 uM, with no significant effect on the c-Myc cells.
VPC-70063 inhibits Myc-Max downstream pathway using UBE2C reporter assay.

Physicochemical Properties

M.Wt 378.336
Formula C16H12F6N2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1-benzyl-3-(3,5-bis(trifluoromethyl)phenyl)thiourea)

References

1. Lavinia A Carabet, et al. Eur J Med Chem. 2018 Dec 5;160:108-119.

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