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VPC-70619

Chemical Structure : VPC-70619

CAS No.: 2361742-30-3

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VPC-70619 (VPC70619)

Catalog No.: PC-72931Not For Human Use, Lab Use Only.

VPC-70619 (VPC70619) is a selective small-molecule inhibitor of N-Myc transcription in NMYC transcription inhibition assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    VPC-70619 (VPC70619) is a selective small-molecule inhibitor of N-Myc transcription in NMYC transcription inhibition assays.
    VPC-70619 blocks DNA binding to N-Myc-Max without disrupting the heterodimer.
    VPC-70619 inhibits N-Myc-dependant cellular growth showing potential selective activity against N-Myc expressing cells.
    At 10 uM, VPC-70619 had an inhibition of 99.4% in IMR32 cells while having a minimal effect of 14% in HO15.19 cells.

    Physicochemical Properties

    M.Wt 364.712
    Formula C16H8ClF3N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-chloro-4-cyano-N'-(4-cyano-2-(trifluoromethyl)phenyl)benzohydrazide

    References

    1. Anh-Tien Ton, et al. Int J Mol Sci. 2022 Feb 26;23(5):2588.

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