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Chemical Structure : VPC01091.4
Catalog No.: PC-21130Not For Human Use, Lab Use Only.
VPC01091.4 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 0.665 uM.
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VPC01091.4 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 0.665 uM.
VPC01091.4 inhibit LPS-induced inflammatory gene expression in macrophages and microglia.
VPC01091.4 reduces systemic peripheral inflammation in a mouse model of LPS-induced endotoxemia.
VPC01091.4 blunts brain and lung inflammation in the mouse model of endotoxemia.
| M.Wt | 303.49 | |
| Formula | C20H33NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Busey GW, et al. J Gen Physiol. 2024 Jan 1;156(1):e202313419.
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