VPC01091.4

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Chemical Structure : VPC01091.4

Catalog No.: PC-21130Not For Human Use, Lab Use Only.

VPC01091.4 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 0.665 uM.

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Biological Activity

VPC01091.4 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 0.665 uM.
VPC01091.4 inhibit LPS-induced inflammatory gene expression in macrophages and microglia.
VPC01091.4 reduces systemic peripheral inflammation in a mouse model of LPS-induced endotoxemia.
VPC01091.4 blunts brain and lung inflammation in the mouse model of endotoxemia.

Physicochemical Properties

M.Wt	303.49
Formula	C20H33NO
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,3R)-1-Amino-3-(4-octylphenyl)cyclopentanemethanol

References

1. Busey GW, et al. J Gen Physiol. 2024 Jan 1;156(1):e202313419.

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VPC01091.4

Biological Activity

Physicochemical Properties

References

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