VPC285785 | SARS-CoV-2 Mpro inhibitor | Probechem Biochemicals

Chemical Structure : VPC285785

VPC285785 (VPC-285785)

Catalog No.: PC-26027Not For Human Use, Lab Use Only.

VPC285785 is a novel covalent inhibitor of the SARS-CoV-2 main protease (Mpro) with IC50 of 0.8 uM, VPC285786 additionally inhibits human cathepsin Lwith IC50 of 4.2 uM.

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Biological Activity

VPC285785 is a novel covalent inhibitor of the SARS-CoV-2 main protease (Mpro) with IC50 of 0.8 uM, VPC285786 additionally inhibits human cathepsin Lwith IC50 of 4.2 uM.
VPC285785 significantly reduced viral load in liver, brain, and spleen tissues compared to vehicle- and Nirmatrelvir-treated controls.

Physicochemical Properties

M.Wt	469.49
Formula	C24H25F2N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2S,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(4,6-difluoro-1H-indole-2-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide

References

1. Jason R Smith, et al. Sci Rep. 2026 Feb 2. doi: 10.1038/s41598-026-36842-2.

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VPC285785 (VPC-285785)

Biological Activity

Physicochemical Properties

References

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