Chemical Structure : VPS18 inhibitor RDN
CAS No.:
1315344-34-3
VPS18 inhibitor RDN
(Riccardin D-N)
Catalog No.: PC-23220Not For Human Use, Lab Use Only.
VPS18 inhibitor RDN is a specific lysosomotropic agent that targeting vacuole protein sorting 18 (VPS18), binds to the RING domain of VPS18, leading to disruption of the VPS-C core complex and lysosomal function.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
VPS18 inhibitor RDN is a specific lysosomotropic agent that targeting vacuole protein sorting 18 (VPS18), binds to the RING domain of VPS18, leading to disruption of the VPS-C core complex and lysosomal function.
VPS18 inhibitor RDN reverses TFE3-mediated drug resistance.
VPS18 inhibitor RDN impaired PD-L1 member trafficking and protein stability.
Combination treatment of RDN and anti-cytotoxic T lymphocyte–associated antigen 4 synergistically enhances antitumor efficacy in aggressive and drug-resistant tumors.
Physicochemical Properties
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M.Wt
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538.69
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Formula
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C34H38N2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3,6:15,18-Dietheno-8,12-metheno-12H-7-benzoxacycloeicosin-9,17,19-triol, 10,20-bis[(dimethylamino)methyl]-1,2,13,14-tetrahydro-
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References
1. Dong T, et al. Sci Adv. 2024 Oct 18;10(42):eadp4917.
2. H. Niu, et al. Signal Transduct. Target. Ther. 6, 224 (2021).
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