VRK1 inhibitor Compound 1 | VRK1 inhibitor

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Chemical Structure : VRK1 inhibitor Compound 1

VRK1 inhibitor Compound 1 (VRK1-IN-1)

Catalog No.: PC-26316Not For Human Use, Lab Use Only.

VRK1 inhibitor Compound 1 (VRK1-IN-1) is a potent, selective and ATP-competitive inhibitor of Vaccinia-related kinase 1 (VRK1) with Ki of 82 nM and IC50 of 154 nM, selective for VRK1 over VRK2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

VRK1 inhibitor Compound 1 (VRK1-IN-1) is a potent, selective and ATP-competitive inhibitor of Vaccinia-related kinase 1 (VRK1) with Ki of 82 nM and IC50 of 154 nM, selective for VRK1 over VRK2.

Physicochemical Properties

M.Wt	346.22
Formula	C14H13Cl2NO3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-butyl-5-(3,5-dichloro-4-hydroxybenzylidene)thiazolidine-2,4-dione

References

1. Crowley-Dolen EK, et al. J Biol Chem. 2026 Mar 6:111355.

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VRK1 inhibitor Compound 1 (VRK1-IN-1)

Biological Activity

Physicochemical Properties

References

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