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VRT-043198

Chemical Structure : VRT-043198

CAS No.: 244133-31-1

VRT-043198 (VRT043198)

Catalog No.: PC-28002Not For Human Use, Lab Use Only.

VRT-043198 is the active metabolite of Belnacasan (VX-765), which is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1, exhibits Ki of 0.8 nM and 0.6 nM for ICE/Caspase-1 and Caspase-4, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VRT-043198 is the active metabolite of Belnacasan (VX-765), which is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/Caspase-1, exhibits Ki of 0.8 nM and 0.6 nM for ICE/Caspase-1 and Caspase-4, respectively.

Physicochemical Properties

M.Wt 480.95
Formula C22H29ClN4O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-3-((S)-1-((S)-2-(4-Amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-4-oxobutanoic acid

References

1. Woods Wannamaker, et al. J Pharmacol Exp Ther. 2007 May;321(2):509-16.

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