Chemical Structure : VTAC-2
CAS No.:
879438-34-3
VTAC-2
(VTAC2)
Catalog No.: PC-28327Not For Human Use, Lab Use Only.
VTAC-2 is a specific, direct small molecule activator of human PANK3 (Pantothenate kinase 3) with EC50 of 76.5 nM, shows no effect on the catalytic activity of hPANK1 or hPANK2.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
VTAC-2 is a specific, direct small molecule activator of human PANK3 (Pantothenate kinase 3) with EC50 of 76.5 nM, shows no effect on the catalytic activity of hPANK1 or hPANK2.
VTAC-2 (1 uM) increased hPanK3 activity to >200% of baseline in the absence of acetyl-CoA and maintained activation at approximately 150% in the presence of 10 μM acetyl-CoA.
VTAC-2 (0, 5, and 20 μM) enhances cellular CoA biosynthesis under physiologically-relevant conditions in HepG2 cells.
VTAC-2 (0, 5, or 20 μM, 24 h) restores CoA levels in both engineered and patient-derived PanK2-deficient cells.
VTAC-2 (20 mg/kg, oral, once daily) stimulateed CoA production in a mouse model of Pantothenate kinase-associated neurodegeneration (PKAN), increased brain CoA in PanK2-deficient mice.
Physicochemical Properties
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M.Wt
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297.36
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Formula
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C16H19N5O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((4-isopropylbenzyl)amino)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
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References
1. Regan J, et al. J Biol Chem. 2026 Sep 17:113567.
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