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VTI-1002

Chemical Structure : VTI-1002

CAS No.:

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VTI-1002 (VTI1002)

Catalog No.: PC-35175Not For Human Use, Lab Use Only.

VTI-1002 is a first-in-class, highly potent, selective inhibitor of human Granzyme B (GzmB) with Ki of 4.4 nM, exhibits strong selectivity for GzmB over caspases 3-10, cathepsin G, and neutrophil elastase.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    VTI-1002 is a first-in-class, highly potent, selective inhibitor of human Granzyme B (GzmB) with Ki of 4.4 nM, exhibits strong selectivity for GzmB over caspases 3-10, cathepsin G, and neutrophil elastase.
    VTI-1002 is nearly 20 times more potent against human GzmB than Ac-IEPD-CHO (Ki=80 nM), exhibits potent inhibition against mouse GzmB (IC50=179 nM).
    VTI-1002 improves remodeling in a murine model of impaired burn wound healing.

    Physicochemical Properties

    M.Wt
    Formula
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    References

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