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Chemical Structure : VU0155069
CAS No.: 1130067-06-9
Catalog No.: PC-63190Not For Human Use, Lab Use Only.
VU0155069 is a potent, selective phospholipase D1 (PLD1) inhibitor with IC50 of 46 nM, 20-fold selectivity over PLD2 (IC50=933 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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VU0155069 is a potent, selective phospholipase D1 (PLD1) inhibitor with IC50 of 46 nM, 20-fold selectivity over PLD2 (IC50=933 nM).
VU0155069 sensitizes MCF7 and MDA-MB-231 breast cancer cells to doxorubicin-induced cytotoxicity.
VU0155069 suppresses growth of colorectal cancer activated by the Wnt/β-catenin and PI3K signaling pathways.
| M.Wt | 462.978 | |
| Formula | C26H27ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-2-naphthalenecarboxamide |
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1. Scott SA, et al. Nat Chem Biol. 2009 Feb;5(2):108-17.
2. Song HI, et al. Sci Rep. 2016 Nov 22;6:36968.
3. Kang DW, et al. Clin Cancer Res. 2017 Dec 1;23(23):7340-7350.
4. Cheng M, et al. Neoplasia. 2017 Aug;19(8):617-627.
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