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VU0424465

Chemical Structure : VU0424465

CAS No.: 1428630-85-6

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VU0424465 (ML273)

Catalog No.: PC-27667Not For Human Use, Lab Use Only.

VU0424465 (ML273) is a potent, selective agonist/positive allosteric modulator (ago-PAM) of mGlu5 receptor with radioligand binding IC50 of 7.3 nM and EC50 of 9.4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VU0424465 (ML273) is a potent, selective agonist/positive allosteric modulator (ago-PAM) of mGlu5 receptor with radioligand binding IC50 of 7.3 nM and EC50 of 9.4 nM.
VU0424465 exhibits high affinity at MPEP allosteric binding site with Ki of 11.8 nM.

Physicochemical Properties

M.Wt 326.37
Formula C19H19FN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-5-((3-Fluorophenyl)ethynyl)-N-(3-hydroxy-3-methylbutan-2-yl)picolinamide

References

1. Manka J, et al. 2011 Dec 16 [updated 2013 Mar 7]. In: Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Hellyer SD, et al. J Neurochem. 2019 Nov;151(3):301-315.

3. Nasrallah C, et al. Sci Rep. 2018 Mar 13;8(1):4407.

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