Chemical Structure : VU0619195
CAS No.:
1206987-73-6
VU0619195
(VU 0619195, VU-0619195)
Catalog No.: PC-27130Not For Human Use, Lab Use Only.
VU0619195 is a small molecule disruptor of ordered membrane domains in cells, destabilize raft formation and decrease protein partitioning reduced the raft affinities of both PMP22 and MAL with EC50 of 1.62 uM and 1.37 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
VU0619195 is a small molecule disruptor of ordered membrane domains in cells, destabilize raft formation and decrease protein partitioning reduced the raft affinities of both PMP22 and MAL with EC50 of 1.62 uM and 1.37 uM.
VU0619195 alters membrane fluidity in vesicles and live cells.
VU0619195 reduces TRPM8 activation in response to menthol stimulation in TRPM8 HEK293T cells.
VU0619195 inhibits activation of KCNQ1/KCNE1.
VU0619195 reduces raft stability through a mechanism that involves both direct interactions with proteins and the disruption of lipid packing.
Physicochemical Properties
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M.Wt
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327.77
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Formula
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C16H14ClN5O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(5-chloro-2-methylphenyl)-5-(phenylamino)-1H-1,2,3-triazole-4-carboxamide
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References
1. Katherine M Stefanski, et al. Proc Natl Acad Sci U S A. 2026 Jun 30;123(26):e2530579123.
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