Catalog No.: PC-60936Not For Human Use, Lab Use Only.
VU 0650786 (VU0650786, VU-0650786) is a potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 392 nM, with no significant activity against other mGlus (IC50>10 uM).
VU 0650786 (VU0650786, VU-0650786) is a potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 392 nM, with no significant activity against other mGlus (IC50>10 uM).
VU 0650786 displays suitability for use in rodent behavioral models, and demonstrates efficacy in models in vivo.
VU 0650786 reverses disrupted contextual fear memory caused by mGlu2/3 agonist LY379268 in vivo.
