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Chemical Structure : VU 0650786
CAS No.: 1809085-30-0
Catalog No.: PC-60936Not For Human Use, Lab Use Only.
VU 0650786 (VU0650786, VU-0650786) is a potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 392 nM, with no significant activity against other mGlus (IC50>10 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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VU 0650786 (VU0650786, VU-0650786) is a potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 392 nM, with no significant activity against other mGlus (IC50>10 uM).
VU 0650786 displays suitability for use in rodent behavioral models, and demonstrates efficacy in models in vivo.
VU 0650786 reverses disrupted contextual fear memory caused by mGlu2/3 agonist LY379268 in vivo.
| M.Wt | 387.799 | |
| Formula | C18H15ClFN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-2-(((5-Chloropyridin-2-yl)oxy)methyl)-5-(2-fluoropyridin-3-yl)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one |
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1. Engers JL, et al. J Med Chem. 2015 Sep 24;58(18):7485-500.
2. Walker AG, et al. Neuropsychopharmacology. 2017 Dec;42(13):2553-2566.
3. Engers JL, et al. ACS Med Chem Lett. 2017 Aug 15;8(9):925-930.
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