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Chemical Structure : VU6010572
Catalog No.: PC-60937Not For Human Use, Lab Use Only.
VU6010572 is a potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 245 nM.
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VU6010572 is a potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 245 nM.
VU6010572 show no inhibition for mGlu2 (IC50>30 uM).
VU6010572 displays improved physiochemical properties and in vivo efficacy in a mouse tail suspension test (MED = 3 mg/kg i.p.).
| M.Wt | 339.366 | |
| Formula | C20H18FNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Engers JL, et al. ACS Med Chem Lett. 2017 Aug 15;8(9):925-930.
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