VU6010572 | mGlu3 NAM | Probechem Biochemicals

Chemical Structure : VU6010572

VU6010572 (VU-6010572)

Catalog No.: PC-60937Not For Human Use, Lab Use Only.

VU6010572 is a potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 245 nM.

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Biological Activity

VU6010572 is a potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 245 nM.
VU6010572 show no inhibition for mGlu2 (IC50>30 uM).
VU6010572 displays improved physiochemical properties and in vivo efficacy in a mouse tail suspension test (MED = 3 mg/kg i.p.).

Physicochemical Properties

M.Wt	339.366
Formula	C20H18FNO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(4-fluorophenyl)-4-(2-phenoxypropoxy)pyridin-2(1H)-one

References

1. Engers JL, et al. ACS Med Chem Lett. 2017 Aug 15;8(9):925-930.

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VU6010572 (VU-6010572)

Biological Activity

Physicochemical Properties

References

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