VVD-338213 | NLRP3 inhibitor | Probechem Biochemicals

Chemical Structure : VVD-338213

VVD-338213 (VVD338213)

Catalog No.: PC-27694Not For Human Use, Lab Use Only.

VVD-338213 is a potent, brain-penetrant, covalent NLRP3 inhibitor with IC50 of 89 nM for inhibiton of IL-1β secretion from human PBMCs, inhibits IL-1β release via preventing inflammasome formation.

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Biological Activity

VVD-338213 is a potent, brain-penetrant, covalent NLRP3 inhibitor with IC50 of 89 nM for inhibiton of IL-1β secretion from human PBMCs, inhibits IL-1β release via preventing inflammasome formation.

Physicochemical Properties

M.Wt	426.87
Formula	C23H20ClFN2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(4R,5S)-1-(but-2-ynoyl)-7-(3-chlorophenyl)-4-(4-fluorophenyl)-4-hydroxy-1,7-diazaspiro[4.4]nonan-6-one

References

1. Rogness DC, et al. Br J Pharmacol. 2026 Aug 8. doi: 10.1111/bph.70626.

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VVD-338213 (VVD338213)

Biological Activity

Physicochemical Properties

References

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