Chemical Structure : VWK147
CAS No.:
VWK147
(VWK-147)
Catalog No.: PC-25911Not For Human Use, Lab Use Only.
VWK147 is a specific second-generation small-molecule inhibitor targeting HSP90 CTD dimerization, induces cell death in cisplatin-sensitive and resistant UC cells (UCCs), and re-sensitizes resistant cells to cisplatin treatment.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
VWK147 is a specific second-generation small-molecule inhibitor targeting HSP90 CTD dimerization, induces cell death in cisplatin-sensitive and resistant UC cells (UCCs), and re-sensitizes resistant cells to cisplatin treatment.
VWK147, but not the N-terminal domain-targeting HSP90 inhibitor 17-AAG, in combination with mTOR inhibitors synergistically kills cisplatin-sensitive and -resistant UCCs.
VWK147 interacts with helices H4 and H5 of the CTD in a manner that would prevent CTD dimerization.
VWK147 destabilizes HSP90 client proteins in urothelial carcinoma cells but does not induce a heat shock response.
VWK147 induces LC3-II accumulation and inhibits autophagosome-lysosome fusion.
VWK147 induces conjugation of ATG8 proteins to single membranes (CASM).
Physicochemical Properties
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M.Wt
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674.72
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Formula
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C32H38N10O7
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-amino-N-(1-(sec-butyl)-2-((1-isobutyl-2-(methylcarbamoyl)-6-oxo-1,6-dihydropyrimidin-5-yl)carbamoyl)-6-oxo-1,6-dihydropyrimidin-5-yl)-1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyrimidine-2-carboxamide
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References
1. David C, et al. Cell Death Dis. 2025 Dec 23. doi: 10.1038/s41419-025-08330-4.
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