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Chemical Structure : VX-11e
CAS No.: 896720-20-0
Catalog No.: PC-43855Not For Human Use, Lab Use Only.
A potent, selective, and orally bioavailable inhibitor of ERK2 with Ki of <2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $100 | In stock | |
| 50 mg | $320 | In stock | |
| 100 mg | $560 | In stock |
Bulk size, bulk discount!
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A potent, selective, and orally bioavailable inhibitor of ERK2 with Ki of <2 nM; shows >200-fold selectivity over GSK3, Aurora A, CDK2, FLT3, etc; significantly inhibits CKAP2 overexpression-induced cell proliferation, migration and invasion in SiHa cells.
| M.Wt | 500.3523 | |
| Formula | C24H20Cl2FN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Pyrrole-2-carboxamide, 4-[2-[(2-chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]- |
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1. Aronov AM, et al. J Med Chem. 2009 Oct 22;52(20):6362-8.
2. Krepler C, et al. Clin Cancer Res. 2016 Apr 1;22(7):1592-602.
3. Guo QS, et al. Sci Rep. 2017 May 18;7(1):2117.
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