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VX-11e

Chemical Structure : VX-11e

CAS No.: 896720-20-0

VX-11e (VX11e)

Catalog No.: PC-43855Not For Human Use, Lab Use Only.

VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK2 with Ki of <2 nM.

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5 mg $78 In stock
10 mg $118 In stock
25 mg $198 In stock
50 mg $328 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK2 with Ki of <2 nM.
VX-11e shows >200-fold selectivity over GSK3, Aurora A, CDK2, FLT3, etc.
VX-11e significantly inhibits CKAP2 overexpression-induced cell proliferation, migration and invasion in SiHa cells.

Physicochemical Properties

M.Wt 500.3523
Formula C24H20Cl2FN5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-Pyrrole-2-carboxamide, 4-[2-[(2-chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-

References

1. Aronov AM, et al. J Med Chem. 2009 Oct 22;52(20):6362-8.

2. Krepler C, et al. Clin Cancer Res. 2016 Apr 1;22(7):1592-602.

3. Guo QS, et al. Sci Rep. 2017 May 18;7(1):2117.

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