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VX-984

Chemical Structure : VX-984

CAS No.: 1562396-65-9

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VX-984 (M9831;VX984)

Catalog No.: PC-61971Not For Human Use, Lab Use Only.

VX-984 (M9831) is a potent, selective inhibitor of DNA-PK with IC50 of 88 nM for inhibition of DNA-PKcs autophosphorylation (Ser2056) in A549 lung cancer cells, with good selectivity versus other PI3K family members.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VX-984 (M9831) is a potent, selective inhibitor of DNA-PK with IC50 of 88 nM for inhibition of DNA-PKcs autophosphorylation (Ser2056) in A549 lung cancer cells, with good selectivity versus other PI3K family members.

Physicochemical Properties

M.Wt 401.4702
Formula C22H19D2N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-[(1S)-1-Methyl-2-[(2'-methyl[4,5'-bipyrimidin]-6-yl-4',6'-d2)amino]ethyl]-4-quinolinecarboxamide

References

1. Harnor SJ, et al. ChemMedChem. 2017 Jun 21;12(12):895-900.

2. D. Boucher, R, et al. AACR; Abstract No. 3716.

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