VY-3-135 | ACSS2 inhibitor | Probechem Biochemicals

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Chemical Structure : VY-3-135

CAS No.: 1824637-41-3

VY-3-135 (ACSS2 inhibitor)

Catalog No.: PC-38179Not For Human Use, Lab Use Only.

VY-3-135 is a potent, specific acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 44 nM, does not inhibits AcCoA synthetase family member ACSS1 and ACSS3.

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5 mg	$178	In stock
10 mg	$288	In stock
25 mg	$478	In stock
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Biological Activity

VY-3-135 is a potent, specific acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 44 nM, does not inhibits AcCoA synthetase family member ACSS1 and ACSS3.
VY-3-135 completely blocked fatty acid synthesis from acetate in SKBr3 cells.
VY-3-135 inhibited mouse TNBC tumor growth in ACSS2high tumors but not ACSS2low tumors.

Physicochemical Properties

M.Wt	429.52
Formula	C26H27N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-Ethyl-2-(hydroxydiphenylmethyl)-N-(2-hydroxypropyl)-1H-benzo[d]imidazole-6-carboxamide

References

1. Miller KD, et al. Cancer Res. 2021 Mar 1;81(5):1252-1264.

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VY-3-135 (ACSS2 inhibitor)

Biological Activity

Physicochemical Properties

References

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