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Chemical Structure : Vacuolin-1
CAS No.: 351986-85-1
Catalog No.: PC-61038Not For Human Use, Lab Use Only.
Vacuolin-1 is a potent PIKfyve inhibitor that inhibits autophagy by impairing lysosomal maturation, potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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Vacuolin-1 is a potent PIKfyve inhibitor that inhibits autophagy by impairing lysosomal maturation, potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A.
Vacuolin-1 blocks the Ca(2+)-dependent exocytosis of lysosomes induced by ionomycin or plasma membrane wounding, without affecting the process of resealing, induces the formation of giant vacuoles.
| M.Wt | 577.4 | |
| Formula | C26H24IN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-4-(2-(3-iodobenzylidene)hydrazinyl)-6-morpholino-N,N-diphenyl-1,3,5-triazin-2-amine |
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1. Cerny J, et al. EMBO Rep. 2004 Sep;5(9):883-8.
2. Shaik GM, et al. Cell Signal. 2009 Aug;21(8):1337-45.
3. Lu Y, et al. Autophagy. 2014;10(11):1895-905.
4. Sano O, et al. FEBS Lett. 2016 Jun;590(11):1576-85.
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